Steer clear of the usage of Promethazine HCl and Codeine Phosphate Oral Solution in adolescents 12 to 18 many years of age who produce other risk elements that could raise their sensitivity towards the respiratory depressant consequences of codeine Until the advantages outweigh the hazards.
If your affected individual develops these signs or signs, elevate the dose towards the prior level and taper more slowly and gradually, possibly by growing the interval in between decreases, decreasing the level of transform in dose, or equally.
Promethazine Promethazine competitively antagonize H1 receptors situated in almost all of the easy muscle including the gastrointestinal tract, uterus, huge blood vessels and bronchial muscle mass. Steps of histamine on H1 receptors improves capillary permeability and edema formation, flare and pruritus.
The concomitant utilization of Promethazine HCl and Codeine Phosphate Oral Answer with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may result in lower codeine ranges, higher norcodeine stages, and fewer metabolism by means of 2D6 with resultant reduced morphine ranges.
Codeine has small plasma protein binding with about seven to twenty five% of codeine certain to plasma proteins. Codeine passes the blood Mind barrier and also the placental barrier. Smaller quantities of codeine and its metabolite, morphine, are transferred to human breast milk.
Bear in mind this medication has become prescribed due to the fact your medical doctor has judged that the profit for you is bigger than the potential risk of Uncomfortable side effects. A lot of people utilizing this medication do not need critical Unwanted effects.
The following significant adverse reactions are explained, or explained in increased detail, in other sections:
Whilst antihistamines are already located to create fetal mortality in rodents, the pharmacological effects of histamine in the rodent usually do not parallel These in man. There won't be any suitable and properly-controlled reports of promethazine in Expecting Females.
Promethazine HCl and Codeine Phosphate Oral Resolution must be utilized with warning in patients with bone- marrow melancholy. Leukopenia and agranulocytosis have been described, generally when promethazine has been Employed in Affiliation with other known marrow-toxic agents.
It can be soluble in water and freely soluble in alcohol. It has a molecular excess weight of 320.88, a molecular system of C17H20N2S•HCI, and the following structural formulation:
Mainly because opioid agonists could maximize biliary tract strain, with resultant increase in plasma amylase or lipase amounts, perseverance of those enzyme amounts may very well be unreliable for 24 hours right after administration of a dose of Promethazine HCl and Codeine Phosphate Oral Remedy.
This product may possibly comprise inactive components, which can bring about allergic reactions or other complications. Speak to your pharmacist For additional details.
Promethazine and codeine may well cause marked drowsiness or may impair the mental and/or Actual physical qualities essential with the performance of potentially hazardous jobs, for instance driving a vehicle or operating equipment.
To help you avert withdrawal, your doctor might lessen your dose bit by bit. Withdrawal is much more very likely For those who have made use of this medication for a long time (quite a lot of weeks) or in superior doses. Explain to your medical doctor or pharmacist instantly Should Promethazine codeine syrup you have withdrawal.